Poster session: Disorders of Platelet Number or Function I, Dec. Since megakaryocytes- which give rise to platelets-can actually be infected by HIV, it is possible that low platelet counts are simply an independent marker of advanced HIV disease, Levine says.Ĭalif. Researchers are unsure why low platelet counts are associated with decreased survival among HIV-infected women, and more study is needed. Interestingly, they also found that African-American women appeared to have significantly less risk of thrombocytopenia than white women, a finding that echoes prior research findings. Researchers found that factors associated with increased risk of thrombocytopenia included HIV infection, low CD4+ lymphocyte counts, increasing viral load, and smoking. Physicians have long relied on counts of CD4+ lymphocyte as a key measure of immunosuppression in HIV-infected patients.įortunately, many women saw their platelet counts boosted back to normal through use of highly active antiretroviral therapy, or HAART, especially therapy containing zidovudine, also called AZT. Levine, M.D., Distinguished Professor of Medicine, chief of hematology at the Keck School of Medicine of USC and medical director of the USC/Norris Cancer Hospital. 'Only a low CD4+ lymphocyte count, one under 200 cells per cubic millimeter, could compare in the strength of its link to mortality,' says WIHS principal investigator Alexandra M. Thrombocytopenia also was linked to a three-fold risk of dying due to AIDS. The researchers found that women with thrombocytopenia-a platelet count of fewer than 50,000 platelets per cubic millimeter-had a five-fold increase risk of dying due to any cause, compared to women with normal platelet counts. Platelets are minute cells in the blood that help in the blood clotting process. When entering the study, 15 percent of HIV-positive women and less than 2 percent of the HIV-negative women had low blood platelet counts, also called thrombocytopenia. In this portion of the study, researchers looked at 1,990 HIV-infected women and 553 HIV-negative women.

5, 2004) - HIV-positive women with low blood platelet counts face significantly higher risk of death compared to women with normal counts, according to a study presented today at the 46th Annual Meeting of the American Society of Hematology.įindings come from the Women's Interagency HIV Study, or WIHS, a prospective study of women living with HIV (as well as HIV-negative women for comparison) in six urban areas across the United States.

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